Real Madrid’s title hopes were dented as Zinedine Zidane’s defending champions were held to a goalless draw at home to Real Betis.
Zidane’s side are two points behind leaders Atletico Madrid, who visit Athletic Bilbao on Sunday.
Rodrygo struck the crossbar with a mis-hit cross as the hosts struggled to find a breakthrough against Manuel Pellegrini’s Europa League hopefuls.
Guido Rodriguez was denied by Thibaut Courtois with Betis’ best chance.
One positive for Real, who beat Cadiz on Wednesday to move top before Atletico responded with victory over Huesca on Thursday, was the return of Eden Hazard after injury.
The Belgium playmaker was introduced as a 77th-minute substitute for his first league appearance since 13 March.
Next up for Real Madrid is their Champions League semi-final first leg tie at home to Hazard’s former club Chelsea on Tuesday.